Bacterial growth inhibition by overproduction of protein

Inhibition of bacterial growth by leucine peptides.

In previous reports (I, 2), data were presented on the growth response of a leucineless mutant (strain 679-680)’ of Escherichia coli strain K-12 to various L-leucine peptides. Measurement of the extent of bacterial growth after 24 hours incubation showed that, at low concentrations, the peptides were almost as effective in the stimulation of growth as was L-leucine; at high concentrations, howe...

INHIBITION OF BACTERIAL GROWTH BY d-LEUCINE*

The present study was undertaken as one approach to an elucidation of the effective structure of the antibiotic, gramicidin (1). The results of investigations of this sort are expected to lead to improved antibiotics, and to experimental approaches to the paths of biological synthesis of ,protein. A striking feature of gramicidin is its content of d-amino acids, notably d-leucine (2). The prese...

Inhibition of bacterial growth by pipradrol.

1 Generously provided by the Win. S. Merrell involved. Since casein hydrolyzate showed conCompany under their trade name of Meratran. siderable activity, and since the activity of It is [a-(2-piperidyl) benzhydrol] hydrochloride, a yeast extract was destroyed by nitrous acid and central stimulant, and is water-soluble and therto some extent by 1 N NaOH, but not by 1 N mostable. HCI, it seemed p...

REOVIRUS GROWTH INHIBITION BY ROTAVIRUS FOLLOWING COINFECTION

REVERSAL OF d-CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE.

Zygmunt, Walter A. (Mead Johnson & Co., Evansville, Ind.). Reversal of d-cycloserine inhibition of bacterial growth by alanine. J. Bacteriol. 84:154-156. 1962.-Reversal of the antibacterial activity of d-4-amino-3-isoxazolidone by alanine in bacterial cultures actively growing on chemically defined media was compared in cultures requiring exogenous alanine and those capable of its synthesis. dl...